First question: why did you up your Wellbutrin dosage? If you were having problems controlling your depression, you could be "crashing" because your disease is being poorly managed at the moment.
I can think of a few: SR and XL have different release patterns. XL has a much slower release that is supposed to occur at a steady amount over the day. It's possible that your metabolism causes this release to "speed up". This isn't crap; liver enzymes do magic things. How were you taking the SR before this day? 2x100mg or 1x200mg?
Also, you went up 100mg in a single day, which is going to cause some side effects, especially the hyper-ness. This goes away after a few days for most people. Two days is not a good amount of time to determine the new effects of an antidepressant. Unless you had a serious reaction, ie suicidality, delusions, you may have wanted to tough it out for those few days to see if it resolved. As I said, for most people, it does. For me, it does, and I'm up to 400 a day as needed.
Changing both doses of medication near each other, plus changing formulations, will in my quasi-professional opinion explain most of the ups and downs you're dealing with. I think you really do need to wait this one out a little more. And again, if you're taking more medication because you're feeling more depressed, and you're still feeling more depressed, it could very likely be your brain and not the meds.
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Date: 2009-05-20 09:47 pm (UTC)I can think of a few:
SR and XL have different release patterns. XL has a much slower release that is supposed to occur at a steady amount over the day. It's possible that your metabolism causes this release to "speed up". This isn't crap; liver enzymes do magic things. How were you taking the SR before this day? 2x100mg or 1x200mg?
Also, you went up 100mg in a single day, which is going to cause some side effects, especially the hyper-ness. This goes away after a few days for most people. Two days is not a good amount of time to determine the new effects of an antidepressant. Unless you had a serious reaction, ie suicidality, delusions, you may have wanted to tough it out for those few days to see if it resolved. As I said, for most people, it does. For me, it does, and I'm up to 400 a day as needed.
Changing both doses of medication near each other, plus changing formulations, will in my quasi-professional opinion explain most of the ups and downs you're dealing with. I think you really do need to wait this one out a little more. And again, if you're taking more medication because you're feeling more depressed, and you're still feeling more depressed, it could very likely be your brain and not the meds.